徐立

男，1976年10月生，广元苍溪人，农学博士，副教授，硕士生导师，全国万名优秀创新创业导师，国家“三区”科技特派员。2006年7月入职西南大学，受聘为副教授，从事教学与科研工作，2008年获评副教授、硕士生导师。主持教育部、重庆市科学技术委员会等省部级及横向科研项目20余项，主研国家级、省部级科研项目30余项；获教育部科技进步奖推广类二等奖1项（排名第11）、农业部中华农业科技奖二等奖1项（排名第12）；获重庆市教学成果奖2项、西南大学教学成果奖2项，教学演讲比赛优秀奖；获评西南大学2016-2018年度、2020-2022 学年度“优秀教师”；在学生科研活动中，两度荣获重庆市“优秀指导教师”。受邀担任重庆、四川、河北、山东、天津、贵州、广西等多省市基金项目与科技奖评审专家；担任Industrial Crops and Products、Journal of Agricultural and Food Chemistry、RSC Advances、Pharmaceutical Biology、Biomedicine & Pharmacotherapy、Food & Function、Phytomedicine、《天然产物研究与开发》《天然产物化学》等国内外期刊审稿人。研究方向：（1）植物次生代谢产物的高效分离与结构鉴定、多靶点生物活性筛选（抗衰老、美白、抗炎、调节代谢、抗病毒、抗菌与神经保护等）、分子作用机制解析与创新功能产品研发；（2）基于植物细胞培养与合成生物技术，高效生物合成医美及医药领域关键紧缺型植物次生代谢产物。讲授课程：（1）本科生课程  《生化分离与分析技术》（专业核心课程）、《天然产物化学》（专业选修课程），西塔老澳门六合彩官网 双语课程《Biochemical substances separation and analysis technology》（专业核心课程）与《Natural products chemistry》（专业选修课程）；（2）研究生课程 《生物医药产业进展》

一、教育及工作经历

教育经历

1996-2000 西南农业大学 蚕丝生物科学            本科

2000-2003 西南农业大学 特种经济动物饲养    硕士

2003-2006 西南大学     特种经济动物饲养     博士

工作经历

2004-2006 中科院昆明植物所植物化学与西部植物资源持续利用国家重点实验室

2006-至今  西南大学                    教师

2015-2016  新加坡国立大学食品系            访问学者

二、代表性科研成果

1. 代表性科研项目

(1)刺梨发酵液抗肿瘤、促组织修复有效成分解析，40万，主持，在研

(2)“桑之谜”系列护肤品的研发，8万，主持，在研

(3)氧化白藜芦醇基于IKK/NF-κB和Nrf2-Keap1信号通路保护急性肝损伤的机制研究，10万，主持，结题

(4)桑椹菌核病早期精准诊断试剂盒的研制及应用示范，20万，主持，已结题

(5)抗桑椹菌核病生物制剂的研发与应用示范，15万，主持，已结题

(6)制备桑叶方便食品的调味料及其桑叶方便食品和制备方法，7万，主持，已结题

(7)桑树功能物质桑皮素A的研究，5万，主持，已结题

(8)桑叶降血脂活性物质的分离纯化研究，5万，主持，已结题

(9)药桑抗炎活性物质的分离纯化与鉴定，4万，主持，已结题

(10)新疆药桑重要活性物质的研究，3.6万，主持，已结题

(11)高压输出电线下植被带的控高增适化学调控研究（1-4期）,32万，主持，已结题

(12)国网重庆市电力公司检修分公司输电线路农药用药技术咨询服务（1-3期），30万，主持，已结题

2.代表性科研论文

(1)Yurong Li, Juanjuan Wei, Zimao Ye, Chen Ji , Wenji Li, Li Xu*, and Zhiqin Zhou*.Essential Oils from Citrus Peels Promote Calcium Overload-Induced Calcicoptosis in U251 Cells[J] Antioxidants, 2025,14(11):1-22

(2)Yanan Jia*, Qiaoyu Li, Fenglin Jiang, Xianzhi Huang, Lingshu Zeng, Yuansong Zhang, Li Xu*. Ultrasonic degradation of mulberry twigs polysaccharides: Effect on in vitro hypoglycemic activity and prebiotic potentialInternational[J] Journal of Biological Macromolecules, 2025,310,143356

(3)Zhihui Jin, Wei Xiang, Xiaowen Shi*, Fenglin Jiang, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Xianzhi Huang and Li Xu*. Identification of compounds against atherosclerosis induced by ox-LDL based on cell extraction/UPLC–MS/MS from mulberry twigs and their mechanistic analysis[J] Chemical and Biological Technologies in Agriculture, 2025, 12(9):1-12

(4)Wei Xiang, Li Xu, Li Zheng, Qiao Zhang, Xiaowen Shi.Purification, structural characterization, and immunoregulatory activity of a polysaccharide from mulberry branch[J] Chemical and Biological Technologies in Agriculture, 2024, 11(39):1-13

(5)Yurong Li, Long Guo, Juanjuan Wei, Yijun Yao, Li Xu*, Zhiqin Zhou*.Effect of polyethoxylated flavonoids (PMFs)-loaded citral and chitosan composite coatings on citrus preservation: From the perspective of fruit resistance[J] Food Chemistry: X, 2024,(22):101417

(6)Shanshan Liu , Xiaowen Shi, Wei Xiang *, Zhihui Jin, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Jiaxin Chen, Xianzhi Huang, Li Xu*. Bioactivities and physicochemical properties of crude polysaccharides from mulberry twigs, agricultural by-products[J] Industrial Crops & Products,2023(193):116191

(7)Xiaowen Shi, Li Xu*, Jianqin Zhang, Juanfen Mo , Pei Zhuang, Li Zheng. Oxyresveratrol from mulberry branch extract protects HUVECs against oxidized Low-density Lipoprotein-induced oxidative injury via activation of the Nrf-2/HO-1 pathway[J] Journal of Functional Foods, 2022,(100)105371.

(8)Pingkang Xu, Qimin Chen, Xiaoman Chen, Hao Qi, Yuyan Yang, Weiqi Li, Xin Yang, Amelia Gunawan, Shuoyu Chen, Huimin Zhang, Han-Ming Shen, Dejian Huang, Brian Kennedy, Li Xu*, Ziyun Wu. Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways[J] GeroScience, 2022,

(9)Fanshan Feng, Wei Xiang*, Han Gao, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Jiaxin Chen, Xianzhi Huang, Li Xu*. Rapid Screening of Nonalkaloid α-Glucosidase Inhibitors from a Mulberry Twig Extract Using Enzyme-Functionalized Magnetic Nanoparticles Coupled with UPLC-MS/MS[J] Journal of Agricultural and Food Chemistry, 2022, 2022, 70,11958−11966

(10)Yuyuan Zhu , Wei Xiang, Yao Shen, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Jiaxin Chen, You Zhou, Xin Xue, Xianzhi Huang, Li Xu*. New butyrylcholinesterase inhibitor derived from mulberry twigs, a kind of agricultural byproducts [J] Industrial Crops & Products, 2022, 187,11535

(11)Lin He, Feifei Huang, Yu Wang, Yijun Wu , Li Xu* and Pingan Chang. The Catalytic Domain of Neuropathy Target Esterase Influences Lipid Droplet Biogenesis and Lipid Metabolism in Human Neuroblastoma Cells[J] Metabolites, 2022, 12, 637.

(12)Wei Xiang, Zhining Xia, Li Xu*. UPLC-MS/MS Profiling, Antioxidant, α-Glucosidase Inhibitory, Cholinesterase Inhibitory, and Cardiovascular Protection Potentials of Jialing 20 (Morus multicaulis Perr.) Mulberry Branch Extract [J] Foods,2021, 10, 2659.

(13)Jing Liu, Yan Yu, Yiping Zhao, Liangyu Jiang, You Zhou, Dejian Huang, Li Xu*. Interrelation of cholesterol-lowering, antioxidant activity and DNA damage protection to the different solvent extracts of mulberry (Morus alba L.) [J] Journal of food processing and preservation, 2020, 45(1): e14891

(14)Ya-Nan Jia, Ya-Lin Peng, Yi-Ping Zhao, Xi-Fei Cheng, You Zhou, Chun-Li Chai, Ling-Shu Zeng, Min-Hui Pan, and Li Xu*. Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs[J] Journal of Agricultural and Food Chemistry,2019, (67)5521-5529

(15)Ya-Nan Jia, Hai-Peng Lu, Ya-lin Peng, Bao-Shun Zhang, Xiao-bao Gong, Jun Su, You Zhou, Min-Hui Pan, Li Xu*. Oxyresveratrol prevents lipopolysaccharide/d galacto- samine induced acute liver injury in mice[J] International Immunopharmacology,2018, (56):105-112

(16)成希飞，杨沙，陈果，赵一萍，彭娅林，周游，徐立*.